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KMID : 0357119790010010045
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Korean Journal of Immunology
1979 Volume.1 No. 1 p.45 ~ p.52
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Bacteriological and Immunological Studies on Panax ginseng
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河大有/Ha, Tai-You
李正鎬/Lee, Jeong-Ho
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Abstract
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The prcesent study was undertaken to evaluate the effects of the Korean Panax ginseng on the immune response in mice. One-half milligram of ginseng extract in 0.25ml volume was given to ICR mice intraperitoneally for 14 days. The ginseng treated and control mice were challenged with sheep red blood cells (SRBC) by intradermal injection 47days after sensitization with varying doses of SRBC by intravenous injection: Such immune responses as delayed-type hypersensitivity (DTH), antibody formation and rosette forming cells with SRBC were measured.
DTH of ginseng treated mice were generally increased than those of control mice. In both groups, the peak responses were shown in the mice sensitized with 1O7SRBC.
Rosettespleen cells of ginseng-treated mice were somewhat increased than those of control mice, and the degree of increment was dependent on the dosage of sensitizing SRBC.
The serum antbody titres were generally decreased in the ginseng treated mice when compared with the control mice. And the titres were shown to be dependent on the antigen doses used for sensitization.
These findings suggest that the Korean ginseng enhances cell-mediated immune response, but depresses the humoral immune response.
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